Indication

This product is indicated for the treatment of: Pain in adults (acute non-specific back pain that is not relieved by non-steroidal anti-inflammatory drugs). This product should not be used in children, unless your doctor decides that the best option is no longer possible.

Directions

Adults (acute non-specific back pain that is not relieved by non-steroidal anti-inflammatory drugs) : Take 1 tablet with water (500mg ibuprofen / 3 tablets of 50 mg acetaminophen or 3 tablets of 600mg ibuprofen / 3 tablets of 600mg aspirin or 2 tablets of 600mg aspirin, if available). Do not take more than 1 tablet in 24 hours.

Usage Advice

• Always store this product in a cool dry place
• Do not use if the product has a seal
• Caution - Keep this product out of reach of children

Ingredients

Each tablet contains: Ibuprofen (3 tablets). Each hard-packed (5g) film-coated tablet contains: Ibuprofen (3 tablets).

Warnings

Do not use if: - You are allergic to ibuprofen, or - You have a stomach ulcer, or - You are taking a medicine called for in a child under 3 years of age. - You are taking aspirin or other NSAIDs in the dose and duration as advised by your doctor. - You are taking other medicines called for in a child under 3 years of age.

Contraindications

Do not use if: - You are allergic to any other painkiller or fever reducer (aspirin, ibuprofen, naproxen, or others). - You are taking any of the following medicines: Ibuprofen or Advil.

Side Effects

Some side effects have been reported with this medicine. You may experience side effects if you take this medicine with: - Alcohol or tobacco

This medicine can cause serious side effects, which are:

• Decreased appetite
• Dizziness
• Headache
• Nausea

Interactions

Do not take ibuprofen or Advil together with aspirin. If you take these medicines together, you may experience the same side effects as you would if you took aspirin.

This medicine may cause stomach bleeding, so you should not take this medicine with any other medicines that you are taking. If you have any questions about the side effects of this medicine, ask your doctor or pharmacist.

Do not use ibuprofen or Advil together with aspirin.

Read all of this leaflet carefully before you use this medicine. If you have any questions, talk to your doctor, pharmacist, or nurse. Try not to use this medicine at the same time as your medicine.Try not to take this medicine if you have taken more than the recommended dose. If you think you have taken too much of this medicine, wash away any excess medicine. If this medicine is not working right away, or if you have any other medicines that you are taking, ask your pharmacist for more information. This may take a little longer to work.

Some of the side effects that have been reported with this medicine include:

Allergy

This medicine may cause an allergic reaction. Stop taking this medicine and get emergency medical help if you have an allergic or other sign of an allergic reaction, such as:

• hives or swelling of the face, lips, tongue or throat
• trouble swallowing or breathing

Some other possible side effects that have been reported with this medicine include:

Precautions

Do not use if: - You are allergic to ibuprofen, or - You are taking any medicine called for in a child under 3 years of age.

If you have a stomach ulcer, you may need to stop taking this medicine.

The University of Colorado at Pompano Beach (UCPB) has received the University of Florida’s Abbreviated Newborn (AN) designation for ibuprofen (Motrin/Advil) and has awarded it to the University of Florida for its significant contribution to research, innovation, and development in the field of infant and childhood nutrition (IUCN) in the United States. The University has received an award in 2016 from the National Institutes of Health (NIH) for the award of the Abbreviated Newborn (AN) designation for Motrin (Advil) and has also received an award from the National Heart, Lung and Blood Institute (NHLBI) for the recognition of its contributions to IUCN research. UCPB is a part of the National Institutes of Health (NIH) National Academy of Child Health and Human Development (NCHED) program. The award recipients are:

• D. M. S. H. (NCHED-I) PhD student, Dr. B., and Dr. E. B., Department of Pediatrics, and Department of Surgery, University of Utah Medical Center, Salt Lake City, UT, USA
• A. C. J. G. (NCHED-I) and Dr.
• S., and Dr. B., Department of Pediatrics, University of Utah Medical Center, Salt Lake City, UT, USA

UCPB is the fourth-largest academic research organization in the country, with over 13,500 members, including more than 10,000 faculty members and staff. UCPB was established in 1986 to support and advance a growing field of research and development in health and care. UCPB is the nation’s largest academic research organization for research in medical and health care. The UCPB is headquartered in Palm Beach, Florida, with more than 100 research institutions and research sites in 15 countries and territories. UCPB’s mission is to serve the academic and medical communities of the United States through research, education, and advocacy in the areas of health, nutrition, and policy. The UCPB’s focus on research, education, and advocacy empowers and advances in health and care. With over a decade of research and development, the UCPB’s commitment to advancing research, education, and advocacy is unparalleled in any other country. With its strong emphasis on science and research, the UCPB is the only academic research organization in the world, dedicated to promoting health and well-being in the world.

UCPB’s research and development program was designed to provide health professionals and researchers with valuable information and knowledge to assist them in their research and development activities. The program is supported by the National Institutes of Health (NIH), the National Science and Technology Museum, and the National Institute of Diabetes and Digestive and Kidney Diseases (NIGD-NED), with a particular focus on research, education, and advocacy. UCPB has a long history of excellence, including research in basic and clinical sciences, epidemiology, and biochemistry, and has conducted more than 100 scientific publications and more than 200 non-peer reviewed publications. In the UCPB, the program is supported by a National Institutes of Health (NIH) grant, and the National Center for Biotechnology Information (NCBI) grant, to which the UCPB is a member. The UCPB is a member of the National Institutes of Health (NIH) Office of National Institutes of Health Education (NKI) and the National Center for Biotechnology Information (NCBI). The UCPB is the world’s largest academic research organization with over 10,000 members in 15 countries and territories. The UCPB’s mission is to serve the academic and medical communities of the United States through research, education, and advocacy in the areas of health, nutrition, and policy. UCPB’s focus on research, education, and advocacy empowers and advances in health and care. The UCPB’s commitment to advancing research, education, and advocacy is unparalleled in any other country. UCPB’s research and development program is supported by the National Institutes of Health (NIH) and the National Science and Technology Museum.

Uses of Ibuprofen

Ibuprofen is used to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis (juvenile rheumatoid arthritis or Still's disease), arthritis of the spine, ankylosing spondylitis, swollen joints, frozen shoulder, bursitis, tendinitis, tenosynovitis, lower back pain, sprains and strains.

It can also be used to treat other painful conditions such as toothache, pain after operations, period pain, headache and migraine.

Therapeutic Category

Ibuprofen: Non-steroidal anti-inflammatory drugs (NSAIDs)

How Ibuprofen works

Ibuprofen works by reducing hormones that cause pain and swelling in the body.

When to consult your doctor

Consult your doctor, if you experience:

• Severe headache, high temperature, stiffness of the neck or intolerance to bright light (aseptic meningitis)
• Passing blood in faeces, black tarry stools, vomiting any blood or dark particles that look like coffee grounds (intestinal bleeding)
• Unexplained stomach pain (abdominal pain) or other abnormal stomach symptoms, indigestion, heartburn, feeling sick and/or vomiting
• Unexplained wheezing, shortness of breath, skin rash, itching or bruising (allergic reaction)
• Loss of vision, blurred or disturbed vision or seeing/hearing strange things (hallucinations)
• Severe skin rash, blistering of skin, including inside mouth, nose, and genitals, as well as skin peeling which may be accompanied with symptoms such as aching, headaches and feverishness (Stevens-Johnson Syndrome, toxic epidermal necrolysis and erythema multiforme)
• Skin rash, fever, swelling of lymph nodes and an increase of eosinophils (DRESS syndrome)

How to take Ibuprofen

The most common side effects of taking Ibuprofen include:

• pain in your back, arms and legs, feeling stomach discomfort, pain in your back, arms and legs when you lie down
• back pain, itching and muscle aches, range of motion and pain in the shoulders and back
• headache, stiffness and blurred vision, fast or irregular heartbeat
• pain in the arm or leg
• tenderness, redness and swelling
• muscle aches and tenderness in the back, arms and legs
• fever and pain in the shoulders and back
• symptoms of heart attack, brain tumors and seizures (convulsions, stroke, or brain herniation)
• unusual tiredness or weakness
• increasedintestinal bleeding

If you experience side effects, you should contact your doctor.

Introduction to Ibuprofen

Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), is commonly used to alleviate pain, inflammation, and fever. It works by blocking the production of prostaglandins, which play a key role in pain signaling. This mechanism helps reduce inflammation, fever, and swelling.

Mechanism of Action

Ibuprofen is classified as a non-steroidal anti-inflammatory drug (NSAID). It functions as a selective inhibitor, inhibiting the enzyme that is responsible for the production of prostaglandins. By blocking the activity of this enzyme, ibuprofen can reduce pain, inflammation, and fever.

Indications and Usage

Ibuprofen is commonly prescribed to alleviate mild to moderate pain and reduce fever. It is also used to treat conditions like headaches, arthritis, and menstrual cramps. It is commonly used in children aged 8 years old and adults.

Benefits of Ibuprofen

• Effective Pain Relieving Effects: Ibuprofen helps alleviate mild to moderate pain, reduce inflammation, and improve mobility and swelling.
• Potential Side Effects: Some individuals may experience stomach upset, diarrhea, and bloating.
• Long-term Use: Ibuprofen is typically used for a longer period of time, up to a year, to provide relief from chronic pain conditions.

How Ibuprofen Works

Ibuprofen works by inhibiting the production of prostaglandins, a type of inflammatory response that can cause pain and inflammation. The enzyme is responsible for the production of prostaglandins, which are substances that are involved in mediating pain and inflammation.

Common Side Effects

• Swelling of the Hands
• Stomach Issues
• Flatulence
• Nausea
• Dizziness
• Heartburn

Interactions

In some cases, ibuprofen may interact with other medications. It is important to inform your healthcare provider about all medications, supplements, or herbal products you are taking before starting treatment. This includes prescription drugs, over-the-counter medicines, and herbal supplements.

Precautions and Contraindications

Before starting ibuprofen, it is important to inform your healthcare provider about any medical conditions you have, including allergies, liver disease, and kidney disease. You should also avoid taking ibuprofen if you have severe heart problems, high blood pressure, or have a history of liver problems.

Pregnant or breastfeeding:

• Avoid using ibuprofen during the first few weeks of pregnancy, as it may harm the unborn baby. It is important to inform your healthcare provider about any medications you are currently taking before starting treatment.
• Avoid using ibuprofen if you are taking other NSAIDs, including naproxen (Aleve) and ibuprofen (Advil), as these can increase the risk of stomach bleeding. Inform your healthcare provider if you have a history of stomach ulcers or other stomach problems.

Bone density:

• Ibuprofen is known to increase bone mineral density, which can negatively affect bone health. It is important to inform your healthcare provider about any medications, supplements, or herbal products you are taking before starting treatment.
• Pregnant or breastfeeding women should avoid ibuprofen during the first few weeks of pregnancy, as it may harm the unborn baby.

Dizziness:

• Ibuprofen can cause dizziness, which may decrease effectiveness and increase drowsiness. Do not drive or operate heavy machinery until you know how ibuprofen affects you.
• It is not known if ibuprofen can cause drowsiness, but it is generally well-tolerated.

Seizures:

• It is not known if ibuprofen can cause seizures, but some individuals may experience seizures when taking this medication.
• It is not known if ibuprofen can cause drowsiness, but some individuals may experience drowsiness when taking this medication.